COVID-19 LEVEL 3 LOCK DOWN
We are operating as usual during lock down, as we are an essential service. Please order in the usual manner. However, due to safety measures in our warehouse and delivery delays, PLEASE ALLOW UP TO A WEEK EXTRA for your delivery.
Most of our stockists either have an on-line store or are operating click and collect. Check their websites for details.
Keep safe everyone!
This article is reprinted courtesy of Petcurean | 5 July 2019 - Updated June 2020
There has been a lot of buzz about a recent US Food and Drug Administration (FDA) statement alerting pet owners about a possible link
between dilated cardiomyopathy (DCM), a type of heart disease, in dogs eating diets containing peas, lentils, potatoes and other legume
seeds as main ingredients. These ingredients are commonly found in diets that are advertised as “grain-free”.1
The statement suggests a potential relationship between the amino acid taurine and DCM in dogs. It is thought that foods with high levels of
peas, potatoes, and lentils may cause low taurine levels in dogs and contribute to heart disease. However, some dogs with DCM on grain-free
diets showed normal blood taurine levels. DCM is also reported to occur in dogs eating diets that are not grain-free.1 Millions
of healthy dogs around the world eat grain-free diets their entire lives; this is the first time that grain-free diets have been implicated
as a potential cause of heart disease. Complicating the matter further is that genetics may also play a role in the development of DCM.2 So,
what is going on? To dive deeper into this issue, we must look at what is currently known about the relationship between diet and the
development of heart disease in dogs.
Taurine is a unique amino acid. Most amino acids are used to make protein, but taurine is a free amino acid in the body.3 Though the exact function of taurine is not entirely understood, it is known to be involved in heart health. In dogs and cats, taurine also plays an important role in activating bile acids in the liver, enabling them to break down fats.3 Cats must get taurine from their diet, but dogs can make taurine using two other amino acids, methionine and cysteine. Therefore, taurine is not considered necessary in dogs’ diets if enough methionine and cysteine are present.3 Although the methionine content in pulses is lower compared to animal-based proteins, this can easily be accounted for by using ingredients rich in this amino acid or using supplementation.4
This is not the first time that diet has been linked to heart disease in dogs. In the early 2000’s, before grain-free diets became mainstream, lamb and rice diets were identified as being correlated with low taurine and heart disease in dogs.5 It was suggested that the lamb meal in these diets did not provide enough methionine and cysteine.5 However, it could not be confirmed that lamb meal was a direct cause of heart disease in dogs. Instead, it was realized that the diet as a whole must be considered to make sure it provides all the nutrients dogs need. This causes one to ask, “why are peas, lentils, and grain-free diets being blamed for causing heart disease in dogs, when we know that ingredients themselves are not the issue?” The challenge is that pointing a finger at ingredients without more in-depth information causes panic and uncertainty for pet parents without providing any fact-based answers or solutions.
In terms of protein, the type is just as important as the amount in the diet. Taurine is naturally found in animal-based proteins. Therefore, diets that contain an adequate level of high-quality animal protein should provide sufficient levels of taurine.6 However, lower quality animal-based proteins (i.e. those that provide low levels of one or more essential amino acid) may not provide adequate methionine and cysteine for dogs to produce enough taurine. Knowing this, it’s critical to consider ingredients’ protein quality when formulating foods for both dogs and cats. Pet foods are also often supplemented with single amino acids, particularly methionine, lysine, and taurine, to ensure they contain sufficient amounts.3
Cooking can also affect protein and amino acids in food. Different formats of pet food (e.g. canned versus kibble) require different
cooking temperatures. Cooking pet food is also required for food safety. However, cooking protein at excessive temperatures can potentially
lead to the destruction of amino acids which can decrease the amount of amino acids available for an animal to use.7 On the flip
side, not cooking ingredients enough can also be an issue. For example, some ingredients in their raw form may contain factors that can
affect the absorption of other nutrients.7 Because of this, it is important that the effects of cooking on amino acid
availability are accounted for when formulating pet foods.
The amount and type of dietary fibre in a food may also affect taurine status. In the body, bile acids joined with taurine support fat
digestion. Bile acids are then reabsorbed in the small intestine to be used again. However, certain types of fibre are thought to bind with
bile acids causing the bile acids to be excreted in the feces rather than reabsorbed.8 When this happens, the body must use more
of its taurine to make bile acids, and this can decrease blood taurine levels. Furthermore, the types of bacteria in the gut may also impact
taurine status. More research is needed to investigate the effects of dietary fibre and gut bacteria on taurine status.
Since the first FDA report was released, there has been a growing body of evidence to suggest that a definitive link between DCM and
specific diets or ingredients cannot be made. Most recently, in June 2020, a highly qualified team of board-certified veterinary
nutritionists, cardiologists and PhD researchers published a literature review on DCM in dogs in the Journal of Animal Science. This review,
which examined more than 200 studies, concluded that there is no definitive evidence to suggest a relationship between grain-free diets and
DCM. The authors further explained that the information that has been distributed to the public thus far has largely been comprised of
incomplete information and conflicting opinions. Based on their review of the literature, the authors stated it is “impossible to draw any
definitive conclusions, in these cases, linking specific diets or specific ingredients to DCM.” 11 Additional research since the
first FDA report has included two research papers which showed that dietary-associated DCM may occur with some grain-free diets,12 but
that the cause is likely multifactorial, resulting from a combination of dietary, metabolic, and genetic factors.13 A
cause-and-effect relationship between DCM and grain-free diets has not been proven.14 Another study published in January 2020
examined the effects of diets containing different carbohydrate sources on taurine status in dogs.15 The results found that there
were no differences in overall taurine status or crude protein digestibility between dogs fed grain-free or grain-inclusive diets. Some
differences in bile acid secretion were observed between the two diet groups, which may indicate that different carbohydrate sources impact
gut bacteria populations and taurine metabolism. However, the effect of these differences needs further study. This was the first study
published in dogs that evaluated the effect of grain-inclusive versus grain-free diets on factors that may contribute to the development of
DCM. This study further supports that a variety of factors in addition to taurine status should be considered when investigating a potential
relationship between DCM and grain-free diets. An in-depth scientific review has also been published on canine diet-associated DCM by an
expert panel of scientists led by researchers at the University of Guelph.16
Overall, it is important to remember that “correlation does not equal causation”. Not all grain-free diets are nutritionally equal,
and it is likely misguided to point fingers at single ingredients or the “grain-free” aspect of diets as the cause of heart disease in dogs.
The evidence shows that the issue is complex with both genetic and dietary factors likely being involved in the development of canine DCM.
While FDA researchers work to uncover science-based facts and compile a comprehensive report, we recommend contacting your veterinarian with
any concerns about your pet’s health.References:
1. CVM Updates – FDA Investigating Potential Connection Between Diet and Cases of Canine Heart Disease. July 12, 2018. Retrieved September 15, 2018, from https://www.fda.gov/animalveterinary/newsevents/cvmupdates/ucm613305.htm2. CVM Updates – FDA Provides Update on Investigation into Potential Connection Between Certain Diets and Cases of Canine Heart Disease. February 19, 2019. Retrieved February 19, 2019, from https://www.fda.gov/AnimalVeterinary/NewsEvents/ucm630993.htm3. CVM Updates - FDA Provides Third Status Report on Investigation into Potential Connection Between Certain Diets and Cases of Canine Heart Disease. June 27, 2019. Retrieved June 27, 2019, from https://www.fda.gov/animal-veterinary/cvm-updates/fda-provides-third-status-report-investigation-potential-connection-between-certain-diets-and-cases4. Backus, R. C., et al., Taurine deficiency in Newfoundlands fed commercially available complete and balanced diets. J. Am. Vet. Med. Assoc. 2003. 223(8): 1130-1136.5. National Research Council. Nutrient Requirements of Dogs and Cats. 2006. Washington, D.C.: The National Academies Press.
6. Boye, J., Zare, F., and A. Pletch. Pulse proteins: Processing, characterization, functional properties and applications in food and feed. Food Res. Int., 2010. 43(2): 414-431.7. Torres, C. L., et al., Taurine status in normal dogs fed a commercial diet associated with taurine deficiency and dilated cardiomyopathy. J. Anim. Physiol. Anim. Nutr. 2003. 87(9-10): 359-372.8. Thompson, A. Ingredients: Where Pet Food Starts. Top. Companion Anim. Med. 2008. 23(3): 127-132.9. Tran, Q. D., Hendricks, W .H., and A.F.B van der Pol. Effects of extrusion processing on nutrients in dry pet food. J. Sci. Food Agric. 2008. 88(9): 1487-1493.10. Stratton-Phelps, M., et al., Dietary Rice Bran Decreases Plasma and Whole-Blood Taurine in Cats. J. Nutr. 2002. 132(6): 1745-1747.11. McCauley, S.R. et al., Review of canine dilated cardiomyopathy in the wake of diet-associated concerns. J. Anim. Sci. 2020. 98(6): skaa155.12. Adin, D., et al., Echocardiographic phenotype of canine dilated cardiomyopathy differs based on diet type. Vet. Card. 2019. 21: 1-9.13. Kaplan, J.L., et al., Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets. PLOS ONE, 2018. 13(12): e0209112.14. Freeman, L. M., et al., Diet-associated dilated cardiomyopathy in dogs: what do we know? J. Am. Vet. Med. Assoc. 2018. 253(11): 1390-1394.15. Pezzali, J.G., et al., Effects of different carbohydrate sources on taurine status in healthy Beagle dogs. J. Anim. Sci. 2020. 98(2): 1-9.16. Mansilla, W.D., et al., Special topic: The association between pulse ingredients and canine dilated cardiomyopathy: addressing the knowledge gaps before establishing causation. J. Anim. Sci. 2019. 97(3): 983-997.
By: Natalie Asaro, Dr. Jennifer Adolphe, & Michele Dixon
Dr. Jennifer Adolphe, Senior Nutritionist at Petcurean, graduated with a rare and coveted Ph.D. in companion animal nutrition from the University of Saskatchewan.Michele Dixon, Health and Nutrition Specialist at Petcurean, studied animal nutrition through Colorado State University and the Companion Animal Sciences Institute.Natalie Asaro, Nutrition Assistant at Petcurean, received both her BSc in Honours Biological Science and MSc in Companion Animal Nutrition from the University of Guelph.